Product Description
| Cat Number | T4657 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | WHI-P97 is a rationally designed potent inhibitor of JAK-3. IC50 value: Target: JAK3 Treatment of mast cells with WHI-P97 inhibited the translocation of 5-lipoxygenase (5-LO) from the nucleoplasm to the nuclear membrane and consequently 5-LO-dependent leukotriene (LT) synthesis after IgE receptor/FcepsilonRI crosslinking by >90% at low micromolar concentrations. WHI-P97 did not directly inhibit the enzymatic activity of 5-LO, but prevented its translocation to the nuclear membrane without affecting the requisite calcium signal. |
| Molecular Weight | 455.1 |
| Purity | 0.9993 |
| Formula | C16H13Br2N3O3 |
| Smiles | COc1cc2ncnc(Nc3cc(Br)c(O)c(Br)c3)c2cc1OC |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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