Product Description
| Cat Number | T4674 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | SB297006 is an antagonist of C-C chemokine receptor 3 (CCR3; IC50 = 39 nM), which normally is activated by eotaxin, eotaxin-3, MCP-3, MCP-4, RANTES, and MIP-1δ. It is at least 250-fold selective for CCR3 over a panel of other chemokine receptors. SB 297006 blocks CCR3-mediated calcium mobilization induced by eotaxin, eotaxin-2, and MCP-4 in transfected cells. It suppresses antigen-induced accumulation of Th2 lymphocytes and eosinophils in lungs of mice when delivered subcutaneously (100 mg/kg). |
| Molecular Weight | 342.35 |
| Purity | 0.9965 |
| Formula | C18H18N2O5 |
| Smiles | CCOC(=O)[C@H](Cc1ccc(cc1)[N+]([O-])=O)NC(=O)c1ccccc1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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