Product Description
| Cat Number | T4687 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Ro5-3335 (CBFβ-Runx1 inhibitor II) is core binding factor (CBF) inhibitor; preferentially kills human leukemia cell lines with CBF fusion proteins (IC50 = 1.1 μM). Ro5-3335 represses RUNX1/CBFβ-dependent transactivation in reporter assays and inhibits transcriptional regulation by RUNX1 and CBFβ. Ro5-3335 also reduces the leukemia burden in a mouse model. Attenuates RUNX1-dependent hematopoiesis in zebrafish embryos. It also is a Tat antagonist and inhibits HIV-1 replication in vitro. |
| Molecular Weight | 259.69 |
| Purity | 0.9995 |
| Formula | C13H10ClN3O |
| Smiles | Clc1ccc2NC(=O)CN=C(c3ccc[nH]3)c2c1 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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