Product Description
| Cat Number | T5437 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Gefitinib-based PROTAC 3, which connects an EGFR binding element to a VHL ligand via a linker, induces EGFR degradation with DC50s of 11.7 nM and 22.3 nM in HCC827 (exon 19 del) and H3255 (L858R mutation) cells, respectively[1]. |
| Molecular Weight | 934.51 |
| Purity | 0.9729 |
| Formula | C47H57ClFN7O8S |
| Smiles | N(C=1C2=C(C=C(OC)C(OCCCCCOCCOCCC(N[C@H](C(=O)N3[C@H](C(NCC4=CC=C(C=C4)C=5SC=NC5C)=O)C[C@@H](O)C3)[C@](C)(C)C)=O)=C2)N=CN1)C6=CC(Cl)=C(F)C=C6 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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