Product Description
| Cat Number | T5465 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | PF-5274857 (PF-5274857 free base) is an effective and selective hedgehog signaling pathway inhibitor (IC50: 5.8 nM and a Ki: 4.6 nM). PF-5274857 is a potentially attractive clinical candidate for the treatment of tumor types including brain tumors and brain metastasis driven by an activated Hh pathway.PF-5274857 was found to effectively penetrate the blood-brain barrier and inhibit Smo activity in the brain of primary medulloblastoma mice, resulting in improved animal survival rates. PF-5274857 was orally available and metabolically stable in vivo. |
| Molecular Weight | 436.96 |
| Purity | 0.9853 |
| Formula | C20H25ClN4O3S |
| Smiles | Cc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCN(CC1)C(=O)CCS(C)(=O)=O |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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