Product Description
| Cat Number | T5S0055 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | 1. Chelidonine (Stylophorin) isolated from Chelidonium majus efficiently induced apoptosis in HeLa cells through possible alteration of p38-p53 and AKT/PI3 kinase signalling pathways. 2. Chelidonine is a promising model compound for overcoming MDR and for enhancing cytotoxicity of chemotherapeutics, especially against leukaemia cells, its efficacy needs to be confirmed in animal models. 3. Chelidonine may be a potential therapeutic agent against metastasis of invasive human cancer cells, exhibits antimigratory and antiinvasive effects in MDA-MB-231 cells, by suppressing COL-induced integrin signaling, through inhibiting the formation of the IPP complex and subsequent downregulation of IPP downstream signaling molecules, such as Akt and ERK1/2. |
| Molecular Weight | 353.37 |
| Purity | 0.9889 |
| Formula | C20H19NO5 |
| Smiles | [H][C@]12[C@@H](O)Cc3cc4OCOc4cc3[C@@]1([H])N(C)Cc1c3OCOc3ccc21 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
Share Item: