Product Description
| Cat Number | T6252 |
|---|---|
| Category | Biochemical |
| Pack Size | 1EA |
| Description | Ipatasertib (GDC-0068) is a selective, ATP-competitive pan-Akt inhibitor that inhibits Akt1 (IC50:5 nM), Akt2 (IC50:18 nM), and Akt3 (IC50:8 nM). Ipatasertib (GDC-0068) can lead to p53-independent PUMA activation by inhibiting Akt, thereby activating FoxO3a and NF-κB simultaneously, directly binding to the PUMA promoter, upregulating PUMA transcription and Bax-mediated intrinsic mitochondrial apoptosis. |
| Molecular Weight | 458 |
| Purity | 0.9921 |
| Formula | C24H32ClN5O2 |
| Smiles | C[C@H]1C2=C(N=CN=C2[C@H](O)C1)N3CCN(C([C@H](CNC(C)C)C4=CC=C(Cl)C=C4)=O)CC3 |
| Storage | -20 ℃ |
| View Document | |
| Note | This product is for Research Use Only |
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