Product Description
| Cat Number | KC-040 |
|---|---|
| Category | Peptide |
| Pack Size | 1 mg |
| Description | TREK-1 channel blocker |
| Modification | None |
| Purity | >95% by hplc |
| Biomarker Target | Potassium channels |
| Sequence Three Letter Code | H-Tyr-Ala-Pro-Leu-Pro-Arg-Trp-Ser-Gly-Pro-Ile-Gly-Val-Ser-Trp-Gly-Leu-Arg-OH |
| Molecular Formula | C96H142N26O22 |
| Sl Sequence | YAPLPRWSGPIGVSWGLR |
| Solubility | Soluble to 2 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| References |
Mazella et al (2010) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design. PLoS Biol. 8 e1000355 PMID: 20405001Borsotto et al (2015) Targeting two-pore domain K(+) channels TREK-1 and TASK-3 for the treatment of depression: a new therapeutic concept. Br.J.Pharmacol. 172 771 PMID: 25263033Djillani A, Pietri M, Mazella J, Heurteaux C, Borsotto M. Fighting against depression with TREK-1 blockers: Past and future. A focus on spadin. Pharmacol Ther. 194 185 PMID: 30291907 Related areasAll peptides >All potassium channel modulators >All neuroscience research categories > |
| Note | The product is for research use only |
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