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Y 27632 dihydrochloride

SKU: BTL-IB-P-00420 | Brand: Isca Biochemical
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Product Description
Cat Number KS-250
Category Peptide
Pack Size 5 mg
Description Rho-associated protein kinase (ROCK) inhibitor
Purity 99% by HPLC, NMR conforms
Biomarker Target Kinases
Sequence Three Letter Code (R)-(+)-trans-4-(1-Aminoethyl)-N-(-4-pyridyl)cyclohexanecarboxamide dihydrochloride
Molecular Formula C14H21N3O.2HCl
Solubility Up to 30 mg per ml in water, freely soluble in DMSO
Appearance White solid
Storage Stable for 2 years from date of purchase as supplied. Stock solutions may be stored at -20° for up to 3 months.
References Uehata et al (1997) Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension. Nature 389 990 PMID: 9353125Ishizaki et al (2000) Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases. Mol Pharmacol. 57(5) 976 PMID: 10779382Lancaster and Knoblich (2014) Generation of cerebral organoids from human pluripotent stem cells. Nat Protoc. 9(10) 2329 PMID: 25188634Hu et al (2015) Direct Conversion of Normal and Alzheimer's Disease Human Fibroblasts into Neuronal Cells by Small Molecules. Cell Stem Cell 7(2) 204 PMID: 26253202Schafer et al (2023) An in vivo neuroimmune organoid model to study human microglia phenotypes. Cell 186(10) 2111 PMID: 37172564
Related areasAll small molecules >All kinase modulators >All stem cell research categories >
Note The product is for research use only
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