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Torin 1

SKU: BTL-IB-P-00398 | Brand: Isca Biochemical

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Product Description

Cat Number	KS-270
Category	Peptide
Pack Size	5 mg
Description	mTOR inhibitor
Purity	98% by HPLC. NMR conforms
Biomarker Target	Kinases
Sequence Three Letter Code	1-[4-[4-(1-Oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-benzo[h]-1,6-naphthyridin-2(1H)-one
Molecular Formula	C35H28F3N5O2
Solubility	Soluble to 1 mM in DMSO with gentle warming
Appearance	White solid
Storage	Store dry, frozen and in the dark
References	Liu et al (2010) Discovery of 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo[h][1,6]naphthyridin-2(1H)-one as a highly potent, selective mammalian target of rapamycin (mTOR) inhibitor for the treatment of cancer. J Med Chem. 53(19) 7146 PMID: 20860370Hong et al (2013) Autophagy sensitivity of neuroendocrine lung tumor cells. Int J Oncol. 43(6) 2031 PMID: 24126619Jhanwar-Uniyal et al (2022) Disentangling the signaling pathways of mTOR complexes, mTORC1 and mTORC2, as a therapeutic target in glioblastoma. Adv Biol Regul. 83 100854 PMID: 34996736 Related areas All small molecules >All kinase modulators >All cancer research categories >All regulated cell death research categories >All pain research categories >
Note	The product is for research use only

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