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PD 325901

SKU: BTL-IB-P-00278 | Brand: Isca Biochemical
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Product Description
Cat Number KS-310
Category Peptide
Pack Size 5 mg
Description MEK inhibitor
Purity 98% by hplc. NMR conforms
Biomarker Target Kinases
Sequence Three Letter Code N-[(2R(-))-2,3-Dihydroxypropoxy]-3,4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]benzamide
Molecular Formula C16H14F3IN2O4
Solubility Soluble in DMSO to 20 mg/ml or ethanol to 20 mg/ml.
Appearance White solid
Storage Store dry, frozen and in the dark
References Barrett et al (2008) The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901. Bioorg Med Chem Lett. 18(24) 6501 PMID: 18952427Ciuffreda et al (2009) Growth-inhibitory and antiangiogenic activity of the MEK inhibitor PD0325901 in malignant melanoma with or without BRAF mutations. Neoplasia 11(8) 720 PMID: 19649202Ai et al (2016) Maintenance of Self-Renewal and Pluripotency in J1 Mouse Embryonic Stem Cells through Regulating Transcription Factor and MicroRNA Expression Induced by PD0325901. Stem Cells Int. 2016:1792573 PMID: 26770202Suo et al (2019)  Inhibition of MAPK/ERK pathway promotes oligodendrocytes generation and recovery of demyelinating diseases. Glia 67(7) 1320 PMID: 30815939Kim and Breton (2022) The MAPK/ERK signaling pathway regulates the expression and localization of Cx43 in mouse proximal epididymis. Biol Reprod. 106(5) 919 PMID: 3515611
Related areasAll small molecules >All kinase modulators >All cancer research categories >All stem cell research categories >
Note The product is for research use only
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