Product Description
| Cat Number | OX-050 |
|---|---|
| Category | Peptide |
| Pack Size | 0.5 mg |
| Description | Endogenous OX1 and OX2 orexin receptor agonist |
| Modification | X is Glp, disulphide bridges between cysteines 6 and 12 and cysteines 7 and 14, C-terminal amide |
| Purity | >95% by hplc |
| Biomarker Target | Orexin receptors |
| Sequence Three Letter Code | Glp-Pro-Leu-Pro-Asp-*Cys-*Cys-Arg-Gln-Lys-Thr-*Cys-Ser-*Cys-Arg-Leu-Tyr-Glu-Leu-Leu-His-Gly-Ala-Gly-Asn-His-Ala-Ala-Gly-Ile-Leu-Thr-Leu-NH2 (*disulphide bridges between cysteines 6 and 12, and cysteines 7 and 14) |
| Molecular Formula | C152H243N47O44S4 |
| Sl Sequence | XPLPDCCRQKTCSCRLYELLHGAGNHAAGILTL-NH2 |
| Solubility | Soluble to 1 mg/ml in water |
| Appearance | Freeze dried solid |
| Storage | Store dry, frozen and in the dark |
| References |
Sakurai et al (1998) Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviour. Cell 92 573 PMID: 9491897Deadwyler et al (2007) Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates. J Neurosci. 27(52) 14239 PMID: 18160631Sakurai (2014) The role of orexin in motivated behaviours. Nat Rev Neurosci. 15(11) 719 PMID: 25301357Guide to Pharmacology - Orexin A Related areasAll peptides >All orexin receptor modulators >All neuroscience categories >All endocrinology categories >All appetite regulation categories > |
| Note | The product is for research use only |
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