Product Description
| Cat Number | PS-020 |
|---|---|
| Category | Peptide |
| Pack Size | 1 mg |
| Description | FRET substrate for beta-secretase 1 (BACE-1) |
| Modification | 7-methoxycoumarin (Mca) at N terminal, 2,4-dintrophenyl on lysine 11, C terminal amide |
| Purity | >95% by HPLC |
| Biomarker Target | Secretases |
| Sequence Three Letter Code | Mca-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Arg-Lys(Dnp)-Arg-Arg-NH2 |
| Molecular Formula | C86H125N27O29 |
| Sl Sequence | Mca-SEVNLDAEFR-K(Dnp)-RR-NH2 |
| Solubility | Soluble in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| References |
Koike et al (1999) Thimet Oligopeptidase Cleaves the Full-Length Alzheimer Amyloid Precursor Protein at a β-Secretase Cleavage Site in COS Cells. J. Biochem. 126(1) 235 PMID: 10393344Klaver et al (2010), Glycosaminoglycan€induced activation of the β€secretase (BACE1) of Alzheimer€™s disease. J. Neurochem. 112 1552 PMID: 20067575 Related areasAll secretase modulators >All fluorescent labelled peptides >All substrate peptides >All neuroscience research areas > |
| Note | The product is for research use only |
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