Product Description
| Cat Number | PS-060 |
|---|---|
| Category | Peptide |
| Pack Size | 1 mg |
| Description | FRET substrate for matrix metalloproteinases |
| Modification | 7-methoxycoumarin (Mca) at the N terminal, X is diaminopropionic acid substituted with 2,4-dinitrophenyl (Dnp), C terminal amide |
| Purity | >95% by HPLC |
| Biomarker Target | Matrix metalloproteases |
| Sequence Three Letter Code | Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 |
| Molecular Formula | C55H80N16O16 |
| Sl Sequence | Mca-KPLGLX(Dnp)AR-NH2 |
| Solubility | Soluble as a stock solution in DMSO |
| Appearance | Freeze dried solid |
| Storage | Store desiccated, frozen and in the dark |
| References |
Neumann et al (2004) Characterization of Mca-Lys-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2, a fluorogenic substrate with increased specificity constants for collagenases and tumor necrosis factor converting enzyme. Anal. Biochem. 328(2) 166 PMID: 15113693Devy et al (2009) Selective inhibition of matrix metalloproteinase-14 blocks tumor growth, invasion, and angiogenesis. Cancer Res. 69(4) 1517 PMID: 19208838Walsh and Damjanovski (2011) IGF-1 increases invasive potential of MCF 7 breast cancer cells and induces activation of latent TGF-β1 resulting in epithelial to mesenchymal transition. Cell. Commun. Signal 9 10 PMID: 21535875 Related areasAll matrix metalloproteases modulators >All fluorescent labelled peptides >All substrate peptides > |
| Note | The product is for research use only |
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