gp100 (280-288) A288V HLA-A*0201 antigen peptide – YLEPGPVTV
SKU: BTL-SP-P-00313 |
Brand: SB Peptide
Product Description
| Cat Number | SB312 |
|---|---|
| Category | Peptide |
| Pack Size | 5 mg |
| Description |
gp100 (280-288) A288V HLA-A*0201 antigen peptide – YLEPGPVTV
SB-PEPTIDE offers gp100 (280-288) A288V variant peptide – YLEPGPVTV for its promising use in immunotherapy.
gp100 protein: potent melanoma-specific antigen
gp100 (Uniprot: P40967) 661 amino acids long type I transmembrane glycoprotein, also known as premelanosome protein (PMEL) for the gene encoding it, is primarily known for its crucial role in melanosome morphogenesis and pigmentation. Indeed, it orchestrates the maturation of these organelles, that are responsible for melanin synthesis, storage, and transport.
More than its implication in melanosome maturation, melanogenesis, biogenesis, and melanin polymerization, gp100 has gained significant attention and recognition as tumor-associated antigen (TAA). Hance, its dynamic and multifaceted nature piqued the interest of researchers and immunobiologists to explore PMEL’s potential in shaping the future of cancer treatment.
gp100 280-288 immunogenic epitope – YLEPGPVTA
Fragments of this protein hold the key to unlocking the body’s natural defense mechanisms against melanoma and have thus been harnessed to develop cancer vaccines. Specifically, gp100 (280-288) HLA-A*0201 epitope – YLEPGPVTA (IEDB: 74638) has exhibited its potential as a robust immunogen, thanks to its capacity to induce cytotoxic T lymphocyte (CTL) responses at remarkably low concentrations ( |
| Disulfide Bonds | _ |
| Note | The product is for research use only |
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