Product Description
| Cat Number | SPR-464E |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100 µg x5 |
| Description | Human Recombinant Transthyretin L55P Variant Protein Filaments |
| Applications | WB | SDS-PAGE | In vivo assay | In vitro assay |
| Target | Transthyretin (TTR) |
| Molecular Weight | 13.876 kDa |
| Cellular Localization | Cytoplasm | Extracellular exosome | Extracellular Region | Lysosome |
| Purity | >95% |
| Research Area | Neuroscience | Neurodegeneration | Alzheimer's Disease | ALS Disease | Tangles & Tau | Parkinson's Disease | Cardiovascular System | Blood | Cell Signaling | Metabolism | Lipid and lipoprotein Metabolism |
| Swiss Prot | P02766 |
| Scientific Background | Transthyretin is a transport protein in the serum and cerebospinal fluid that carried the thyroid hormone Thyroxine and retinol-binding protein bound to retinol. TTR misfolding and aggregation is known to be associated with the amyloiddiseases SSA, FAP and FAC (1-5). TTR is also thought to have beneficial side effects, such as binding to beta-amyloid protein, preventing beta-amyloid from accumulating into the plaques associated with Alzheimer's Disease (6). The L55P variant TTR is distinct from the other variants in that the L55P tetramer can dissociate to the monomeric amyloidogenic intermediate and form fibril precursors (7). |
| Expression System | E. coli |
| Accession Number | NP_000362.1 |
| Gene Id | 7276 |
| Protein Length | Full length |
| Purification | Ion-exchange Purified |
| Storage | -80ºC |
| References | 1. Zeldenrust S.R., Benson M.D. (2010). Wiley. pp. 795–815. 2. Westermark P., Sletten K., Johansson B., Cornwell G.G. (1990). Proc. Natl. Acad. Sci. U.S.A. 87(7): 2843–5. 3. Andrade C. (1952). Brain. 75(3): 408–27. 4. Coelho T. (1996). Curr. Opin. Neurol. 9(5): 355–9. 5. Jacobson D.R, et. al. (1997). N. Engl. J. Med. 336(7): 466–73. 6. Li X. (2011). Mol Neurodegener. 6(1):79. 7. Lashuel H.A., Wurth C., Woo L., and Kelly J.W. (1999) Biochem. 38(41): 13560-13573. |
| Product Url | View Document |
| Note | The product is for research use only |
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