Alpha Synuclein Oligomers (Dopamine HCL Stabilized)
SKU: BTL-SM-P-00160 |
Brand: Stressmarq
Product Description
| Cat Number | SPR-466B |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100 µg |
| Description | Human Recombinant Alpha Synuclein Oligomers (Dopamine HCL Stabilized) |
| Applications | WB | SDS-PAGE | In vivo assay | In vitro assay |
| Target | Alpha Synuclein Oligomers |
| Molecular Weight | ~14.46kDa |
| Cellular Localization | Cytoplasm | Membrane | Nucleus |
| Purity | >95% |
| Research Area | Neuroscience | Neurodegeneration | Alzheimer's Disease | Tangles & Tau | Neuroscience | Neurodegeneration | Parkinson's Disease | Synuclein | Neuroscience | Neurodegeneration | Multiple System Atrophy |
| Swiss Prot | P37840 |
| Scientific Background | Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Dopamine inhibits alpha synuclein fibrillogenesis leading to oligomer accumulation in vitro (7), (8) and in vivo (9), (10). |
| Expression System | E. coli |
| Accession Number | NP_000336.1 |
| Gene Id | 6622 |
| Protein Length | Full length |
| Purification | Ion-exchange Purified. Monomeric alpha synuclein was removed via filtration. |
| Storage | -80ºC |
| References | 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013). 2. Zhang L., et al. (2008) Brain Res. 1244: 40-52. 3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117. 4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230. 5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840. 6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757. 7. Conway, K.A. et al. (2001) Science 294:1346-1349. 8. Norris, E.H. et al. (2005) J Biol Chem. 280:21212-21219. 9. Mazulli, J.R. et al. (2006). J Neurosci. 26:10068-10078. 10. Mazulli, J.R. et al. (2007). J Biol Chem. 282:31621-31630. |
| Product Url | View Document |
| Note | The product is for research use only |
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