CGRP: A Biomarker for Migraine

CGRP is a neuropeptide that plays a significant role in the nervous system and is involved in various physiological processes.

Structure: CGRP is a 37-amino acid peptide
It is produced in both the central and peripheral nervous systems

Physiological Roles:
· Vasodilation: CGRP is a potent vasodilator, meaning it can widen blood vessels. This is important in regulating blood flow and blood pressure
· Pain Transmission: It is involved in the transmission of pain signals, particularly in the context of migraine headaches
· Neurotransmission: CGRP acts as a neurotransmitter and neuromodulator, influencing various neuronal functions

CGRP plays a significant role in migraine, as elevated levels in the blood and cerebrospinal fluid contribute to the condition. CGRP causes the dilation of blood vessels (vasodilation) and activates the trigeminal nerve, which transmits pain signals. These combined actions result in the characteristic pain and other symptoms associated with migraines.

To advance research in this field, BTL Biotechno Labs Pvt. Ltd. an authorised distributor of Biorbyt offers their ELISA kits, recombinant proteins, antibodies, and small molecule products for measuring CGRP in various species to the Indian scientific community at competitive prices.

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