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Therapeutic gene transfer using retrovirus

By: Team BTL Biotechno Labs Pvt. Ltd.

Therapeutic gene transfer using retrovirus- and lentiviral vectors into stem cells has been used in recent breakthrough therapies. Applications of CD34+ stem cell gene therapies are also currently being extended to the prevention or treatment of HIV. Currently, there is great interest in optimizing protocols for clinical use for lentivirus-mediated gene delivery into primary cells, particularly into CD34+ Hematopoietic stem cells (HSC). Oz biosciences has come up with a solution for this by providing LentiBlast Premium Superior Grade. It is the ideal reagent to enhance lentiviral infection and transduction in CD34+ hematopoietic stem cells, T lymphocytes as well as any other cells.

It is identical in synthesis and formulation to LentiBlast Premium Transduction Enhancer with advanced quality controls. It is designed for use in preclinical and early phase clinical trials and can be used as an ancillary material for cell & gene therapy.

Its patented chemical composition allows to simultaneously neutralize electrostatic repulsions between membrane and viral particles and to enhance viral fusion with cell membrane. LentiBlast Premium Superior Grade limits any transmembrane potential changes and thus facilitates virus entry.