WEISLAB Complement System Alternative Pathway

The alternative pathway is a type of cascade reaction of the complement system and is a component of the innate immune system, a natural defense against infections.
The alternative pathway is one of three complement pathways that opsonize and kill pathogens. The pathway is triggered when the C3b protein directly binds a microbe. It can also be triggered by foreign materials and damaged tissues. Dysregulation of the complement system has been implicated in several diseases and pathologies, including Atypical hemolytic uremic syndrome, in which kidney function is compromised. Alternative pathway activation also plays a significant role in complement-mediated renal disorders such as atypical hemolytic uremic syndrome, C3 glomerulopathy, and C3 glomerulonephritis (Dense Deposit Disease, or MPGN Type II).
BTL Biotechno Labs Pvt. Ltd., a reliable channel partner of SVAR Life Science, offers their Wieslab® Complement assay to the Indian scientific community, which combines principles of the hemolytic assay for complement activation with the use of labeled antibodies specific for neoantigens produced as a result of complement activation. The amount of neoantigen generated is proportional to the functional activity of complement pathways.

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