Cytochrome C (Mitochondrial Marker)(6H2.B4), CF405S conjugate, 0.1mg/mL
SKU: BTL-BIT-B-01225 |
Brand: Biotium
Product Description
| Cat Number | BNC040184-100 |
|---|---|
| Category | Biochemical |
| Pack Size | 1 EA |
| Description | Cytochrome c is a well-characterized mobile electron transport protein that is essential to energy conversion in all aerobic organisms. In mammalian cells, this highly conserved protein is normally localized to the mitochondrial inter-membrane space. More recent studies have identified cytosolic cytochrome c as a factor necessary for activation of apoptosis. During apoptosis, cytochrome c is trans-located from the mitochondrial membrane to the cytosol, where it is required for activation of caspase-3 (CPP32). Overexpression of Bcl-2 has been shown to prevent the translocation of cytochrome c, thereby blocking the apoptotic process. Overexpression of Bax has been shown to induce the release of cytochrome c and to induce cell death. The release of cytochrome c from the mitochondria is thought to trigger an apoptotic cascade, whereby Apaf-1 binds to Apaf-3 (caspase-9) in a cytochrome c-dependent manner, leading to caspase-9 cleavage of caspase-3. |
| Storage | PBS, 0.1% BSA, 0.05% azide |
| Note | The product is for research use only |
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