CD63 (Late Endosomes Marker)(LAMP3/529), CF405S conjugate, 0.1mg/mL
SKU: BTL-BIT-B-01666 |
Brand: Biotium
Product Description
| Cat Number | BNC040529-500 |
|---|---|
| Category | Biochemical |
| Pack Size | 1 EA |
| Description | This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. Its epitope is different from that of MAb LAMP3/803 or LAMP3/968 or NKI/C3 or MX-49.129.5. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression._x000D_ _x000D_ |
| Storage | PBS, 0.1% BSA, 0.05% azide |
| Note | The product is for research use only |
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