GITR / Tnfrsf18 (Mouse)(DTA-1), CF405S conjugate, 0.1mg/mL
SKU: BTL-BIT-B-02294 |
Brand: Biotium
Product Description
| Cat Number | BNC040976-500 |
|---|---|
| Category | Biochemical |
| Pack Size | 1 EA |
| Description | GITR (glucocorticoid-induced TNFR-related gene) is a member of the TNF-receptor superfamily, also known as TNFRSF18. It is expressed at low levels on resting T lymphocytes and at high levels on CD25 CD4 Tregs. The expression of GITR on T cells can be upregulated upon activation. Interaction of GITR with its ligand (GITRL) has been demonstrated to augment T cell activation, proliferation, cytokine production as well as MAPKs and NF-B activation, and abrogate the inhibitory function ofCD25 CD4 Tregs. In vivo activation of GITR causes development of autoimmune diseases and restores the suppressed immune response. |
| Storage | PBS, 0.1% BSA, 0.05% azide |
| Note | The product is for research use only |
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