CD63 (Late Endosomes Marker)(NKI/C3 + LAMP3/968), CF405S conjugate, 0.1mg/mL
SKU: BTL-BIT-B-02540 |
Brand: Biotium
Product Description
| Cat Number | BNC041160-500 |
|---|---|
| Category | Biochemical |
| Pack Size | 1 EA |
| Description | This MAb recognizes protein of 26 kDa-60 kDa, which is identified as CD63. The tetraspanins are integral membrane proteins expressed on cell surface and granular membranes of hematopoietic cells and are components of multi-molecular complexes with specific integrins. The tetraspanin CD63 is a lysosomal membrane glycoprotein that translocates to the plasma membrane after platelet activation. CD63 is expressed on activated platelets, monocytes and macrophages, and is weakly expressed on granulocytes, T cell and B cells. It is located on the basophilic granule membranes and on the plasma membranes of lymphocytes and granulocytes. CD63 is a member of the TM4 superfamily of leukocyte glycoproteins that includes CD9, CD37 and CD53, which contain four transmembrane regions. CD63 may play a role in phagocytic and intracellular lysosome-phagosome fusion events. CD63 deficiency is associated with Hermansky-Pudlak syndrome and is strongly expressed during the early stages of melanoma progression. |
| Storage | PBS, 0.1% BSA, 0.05% azide |
| Note | The product is for research use only |
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