CD7 (T-Cell Leukemia Marker)(HuLy-m2), CF405S conjugate, 0.1mg/mL
SKU: BTL-BIT-B-02663 |
Brand: Biotium
Product Description
| Cat Number | BNC041252-100 |
|---|---|
| Category | Biochemical |
| Pack Size | 1 EA |
| Description | Recognizes a protein of 40 kDa, identified as CD7 (Workshop IV; Code T165). CD7 is a member of the immunoglobulin gene superfamily. Its N-terminal amino acids 1-107 are highly homologous to Ig kappa-L chains whereas the carboxyl-terminal region of the extracellular domain is proline-rich and has been postulated to form a stalk from which the Ig domain projects. CD7 is expressed on the majority of immature and mature T-lymphocytes, and T cell leukemia. It is also found on natural killer cells, a small subpopulation of normal B cells and on malignant B cells. Cross-linking surface CD7 positively modulates T cell and NK cell activity as measured by calcium fluxes, expression of adhesion molecules, cytokine secretion and proliferation. CD7 associates directly with phosphoinositol 3'-kinase. CD7 ligation induces production of D-3 phosphoinositides and tyrosine phosphorylation. |
| Storage | PBS, 0.1% BSA, 0.05% azide |
| Note | The product is for research use only |
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