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AM 251

SKU: BTL-IB-P-00041 | Brand: Isca Biochemical

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Product Description

Cat Number	CB-010
Category	Peptide
Pack Size	10 mg
Description	CB1 receptor inverse agonist
Purity	98% by TLC , NMR conforms
Biomarker Target	μ Opioid receptors,Cannabinoid receptors
Sequence Three Letter Code	N-(Piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide
Molecular Formula	C22H21Cl2IN4O
Solubility	Soluble in DMSO to 50 mg/ml or ethanol to 13 mg/ml
Appearance	Off-white solid
Storage	Store dry, frozen and in the dark
References	Lan et al (1999) Structure-activity relationships of pyrazole derivatives as cannabinoid receptor antagonists. J Med Chem. 42(4) 769 PMID: 10052983Shearman et al (2003) Antidepressant-like and anorectic effects of the cannabinoid CB1 receptor inverse agonist AM251 in mice. Behav Pharmacol. 4(8) 573 PMID: 14665974Seely et al (2012) AM-251 and rimonabant act as direct antagonists at mu-opioid receptors: implications for opioid/cannabinoid interaction studies. Neuropharmacology 63(5) 905 PMID: 22771770Ueda et al (2014) Cannabinoid receptor type 1 antagonist, AM251, attenuates mechanical allodynia and thermal hyperalgesia after burn injury. Anesthesiology 21(6) 1311 PMID: 25188001 Related areas All small molecules >All cannabinoid receptor modulators >All μ opioid receptor modulators >All pain research categories >All neuroscience research categories >
Note	The product is for research use only

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