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Maraviroc

SKU: BTL-IB-P-00198 | Brand: Isca Biochemical

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Product Description

Cat Number	CK-060
Category	Peptide
Pack Size	5 mg
Description	CCR5 antagonist
Purity	>98% by HPLC, NMR conforms
Biomarker Target	Chemokine receptors,Antivirals
Sequence Three Letter Code	4,4-Difluoro-N-[(1S)-3-[(1R,5S)-3-(3-methyl-5-propan-2-yl-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octan-8-yl]-1-phenylpropyl]cyclohexane-1-carboxamide
Molecular Formula	C29H41F2N5O
Solubility	Soluble in DMSO to 25 mg/ml
Appearance	White solid
Storage	Store dry, frozen and in the dark
References	Dorr et al (2005) Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother. 49(11) 4721 PMID: 16251317Velasco-VelÃ¡zquez et al (2012) CCR5 antagonist blocks metastasis of basal breast cancer cells. Cancer Res. 72(15) 3839 PMID: 22637726Woollard and Kanmogne (2015) Maraviroc: a review of its use in HIV infection and beyond. Drug Des Devel Ther. 9 5447 PMID: 26491256Zi et al (2017) Treatment with the C-C chemokine receptor type 5 (CCR5)-inhibitor maraviroc suppresses growth and induces apoptosis of acute lymphoblastic leukemia cells. Am J Cancer Res. 7(4) 869 PMID: 28469959Aldinucci et al (2020) The CCL5/CCR5 Axis in Cancer Progression. Cancers (Basel) 12(7) 1765 PMID: 32630699 Related areas All small molecules >All chemokine receptor modulators >All antivirals >All cancer research categories >All immunology research categories >
Note	The product is for research use only

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