Human CTLA-4/CD152 Protein (CTL-HM141)
SKU: BTL-KB-P-01146 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | CTL-HM141 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human CTLA-4/CD152 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys36-Asp161. |
| Target | CTLA-4/CD152 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
| Scientific Background | CTLA-4 (cytotoxic T-lymphocyte-associated protein 4), also known as CD152, is a protein receptor that, functioning as an immune checkpoint, downregulates immune responses.CTLA4 is constitutively expressed in regulatory T cells but only upregulated in conventional T cells after activation – a phenomenon which is particularly notable in cancers. It acts as an "off" switch when bound to CD80 or CD86 on the surface of antigen-presenting cells. |
| Molecular Mass | The protein has a predicted MW of 14.3 kDa. Due to glycosylation, the protein migrates to 28-35 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Lys36-Asp161 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P16410-1 |
| Amino Acid Sequence | Recombinant Human CTLA-4/CD152 Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Lys36-Asp161. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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