Cynomolgus FLT3/Flk-2 Protein (FLT-CM230)
SKU: BTL-KB-P-01495 |
Host: Cynomolgus |
Brand: Kactus Bio
Product Description
| Cat Number | FLT-CM230 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Cynomolgus FLT3/Flk-2 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln28-Ser541. |
| Target | FLT3/Flk-2 |
| Host | Cynomolgus |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Scientific Background | The Flt-3 (fms-like tyrosine kinase) receptor, also named Flk-2 (fetal liver kinase) and Stk-1(stem cell tyrosine kinase) is a member of the class III subfamily of receptor tyrosine kinases that also includes KIT, the receptor for SCF and FMS, the receptor for M-CSF. Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. |
| Molecular Mass | The protein has a predicted MW of 84.58 kDa. Due to glycosylation, the protein migrates to 160-180 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Gln28-Ser541 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | A0A2K5VQ48 |
| Amino Acid Sequence | Recombinant Cynomolgus FLT3/Flk-2 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln28-Ser541. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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