Biotinylated Human GCGR/Glucagon receptor Nanodisc (GCR-HM10NB)
SKU: BTL-KB-P-01605 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | GCR-HM10NB |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Biotinylated Human GCGR/Glucagon receptor Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Phe477. |
| Target | GCGR/Glucagon receptor |
| Host | Human |
| Scientific Background | The pancreatic hormone glucagon activates the glucagon receptor (GCGR), a class B seven-transmembrane G protein-coupled receptor that couples to the stimulatory heterotrimeric G protein and provokes PKA-dependent signaling cascades vital to hepatic glucose metabolism and islet insulin secretion. The GCGR expressed at the plasma membrane is constitutively ubiquitinated and upon agonist-activation, internalized GCGRs are deubiquitinated at early endosomes and recycled via Rab4-containing vesicles. |
| Molecular Mass | The protein has a predicted MW of 66.9 kDa. |
| Sl Sequence | Met1-Phe477 |
| Appearance | Liquid |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P47871 |
| Amino Acid Sequence | Recombinant Biotinylated Human GCGR/Glucagon receptor Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Phe477. |
| Storage | Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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