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Exendin-4

SKU: BTL-IB-P-00121 | Brand: Isca Biochemical
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Product Description

Cat Number GH-001
Category Peptide
Pack Size 1 mg
Description Glucagon like peptide 1 (GLP-1) receptor agonist
Modification C terminal amide
Purity >95% by HPLC
Biomarker Target Glucagon and related receptors
Sequence Three Letter Code H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-Asn-His-NH2
Molecular Formula C184H282N50O60S
Sl Sequence HGEGTFTSDLSKQMEEEAVRLFIEWLKNGGPSSGAPPPS-NH2
Solubility Soluble in water (10mg/mL), PBS, dilute acid and DMSO.
Appearance Freeze dried solid
Storage Store desiccated at -20°C in the dark
References Eng et al (1992) Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. J.Biol.Chem. 267 7402 PMID: 1313797Goke et al (1993) Exendin-4 is a high potency agonist and truncated exendin-(9-39)-amide an antagonist at the glucagon-like peptide 1-(7-36)-amide receptor of Ins-Secr.g β-cells. J.Biol.Chem. 268 19650 PMID: 8396143Varin et al (2016) Inhibition of the MAP3 kinase Tpl2 protects rodent and human β-cells from apoptosis and dysfunction induced by cytokines and enhances anti-inflammatory actions of exendin-4. Cell Death Dis. 7 e2065 https://doi.org/10.1038/cddis.2015.399
Related areas
All peptides >All glucagon and related receptor modulators >All endocrinology research categories >All diabetes research categories >
Note The product is for research use only
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