Product Description
| Cat Number | GMP-CKS-HE007 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 50UG |
| Description | Recombinant GMP Human IL-7 is expressed from E.coli without tag.It contains Asp26-His177. |
| Target | IL-7 |
| Host | Human |
| Purity | ≥ 95% as determined by SEC-HPLC. |
| Scientific Background | Interleukin (IL)-7 is a non-redundant cytokine in T-cell development and function. It is required in early T-cell development as well as for T-cell homeostasis and is secreted by stromal cells in the thymic and bone marrow (BM) environment. IL-7 binds to its receptor which is composed of the two chains IL-7Rα (CD127), shared with the thymic stromal lymphopoietin (TSLP), and the common γ chain (CD132) for IL-2, IL-15, IL-9 and IL-21. Whereas γc is expressed by most hematopoietic cells, IL-7Rα is nearly exclusively expressed on lymphoid cells. After binding to its receptor, IL-7 signals through two different pathways: Jak-Stat (Janus kinase-Signal transducer and activator of transcription) and PI3K/Akt responsible for differentiation and survival, respectively. |
| Molecular Mass | The protein has a predicted MW of 17.5 kDa same as Bis-Tris PAGE result. |
| Sl Sequence | Asp26-His177 |
| Solubility | Please refer to the Certificate of Analysis for detailed instructions. |
| Appearance | Lyophilized |
| Endotoxin Levels | ≤ 0.01 EU per μg by the LAL method. |
| Expression System | E.coli |
| Gene Id | P13232 |
| Amino Acid Sequence | Recombinant GMP Human IL-7 is expressed from E.coli without tag.It contains Asp26-His177. |
| Storage | The product is shipped with ice bag. Store it immediately at -20°C±5°C upon arrival. ；-20°C±5°C for 36 months in lyophilized state. ；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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