Product Description
| Cat Number | GT-010 |
|---|---|
| Category | Peptide |
| Pack Size | 1 mg |
| Description | K-Ras inhibitor |
| Modification | N terminal is acetylated, C terminal is amidated, disulfide bridge between cysteines 5 and 15 |
| Purity | >95% by hplc |
| Biomarker Target | GTPases |
| Sequence Three Letter Code | Ac-Arg-Arg-Arg-Arg-Cys*-Pro-Leu-Tyr-Ile-Ser-Tyr-Asp-Pro-Val-Cys*-Arg-Arg-Arg-Arg-NH2; disulfide bridge between cysteines 5 and 15 |
| Molecular Formula | C109H183N43O25S2 |
| Sl Sequence | Ac-RRRRC*PLYISYDPVC*RRRR-NH2 |
| References |
Niida et al (2017) Investigation of the structural requirements of K-Ras(G12D) selective inhibitory peptide KRpep-2d using alanine scans and cysteine bridging. Bioorg Med Chem Lett. 27(12) 2757 PMID: 28457754Sakamoto et al (2017) K-Ras(G12D)-selective inhibitory peptides generated by random peptide T7 phage display technology. Biochem Biophys Res Commun. 484(3) 605 PMID: 28153726Lim et al (2021) Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling. Chem Sci. 12(48) 15975 PMID: 35024121 Related areasAll peptides >All GTPase modulators >All cancer research categories > |
| Note | The product is for research use only |
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