Human IGF1R/CD221 Protein (IGF-HM11R)
SKU: BTL-KB-P-01869 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | IGF-HM11R |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu31-Asn932. |
| Target | IGF1R/CD221 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
| Scientific Background | The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target. |
| Molecular Mass | The protein has a predicted MW of 80.4 kDa (alpha subunit) and 24.1 kDa (beta subunit). Due to the furin cleavage site and glycosylation, the protein migrates to 110-130 kDa and 45-55 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Glu31-Asn932 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P08069 |
| Amino Acid Sequence | Recombinant Human IGF1R/CD221 Protein is expressed from HEK293 with His tag at the C-terminus.It contains Glu31-Asn932. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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