Biotinylated Human IL-23 alpha&IL-12 beta Protein (IL2-HM4ABB)
SKU: BTL-KB-P-01991 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | IL2-HM4ABB |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Biotinylated Human IL-23 alpha&IL-12 beta Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of IL-23 alpha.It contains Arg20-Pro189 (IL-23 alpha) and Ile23-Ser328 (IL-12 beta). |
| Target | IL-23 alpha&IL-12 beta |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | The interleukin (IL)-12 family of cytokines, including IL12 and IL 23, play an important role in driving aberrant Th1 and Th17 immune responses in patients with Crohn's disease (CD). Targeting this pathway has opened new avenues for therapeutic intervention. The balance of proinflammatory cytokines interleukin (IL)-12 and IL-23 plays a key role in shaping the development of antitumor or protumor immunity. |
| Molecular Mass | The protein has a predicted MW of 21.7 kDa (IL-23 alpha) and 34.7 kDa (IL-12 beta). Due to glycosylation, the protein migrates to 24 kDa (IL-23 alpha) and 40-50 kDa (IL-12 beta) based on Bis-Tris PAGE result. |
| Sl Sequence | Arg20-Pro189(IL-23 alpha) & Ile23-Ser328(IL-12 beta) |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | Q9NPF7(IL-23 alpha)&P29460(IL-12 beta) |
| Amino Acid Sequence | Recombinant Biotinylated Human IL-23 alpha&IL-12 beta Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus of IL-23 alpha.It contains Arg20-Pro189 (IL-23 alpha) and Ile23-Ser328 (IL-12 beta). |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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