Human IL-2 R beta&IL-2 R gamma Protein (ILR-HM2BG)
SKU: BTL-KB-P-02166 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | ILR-HM2BG |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human IL-2 R beta&IL-2 R gamma Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus of IL-2 R beta and IL-2 R gamma.It contains Ala27-Thr240 (IL-2 R beta) and Leu23-Ala262 (IL-2 R gamma). |
| Target | IL-2 R beta&IL-2 R gamma |
| Host | Human |
| Purity | > 90% as determined by Bis-Tris PAGE |
| Scientific Background | Wilms' tumor 1 (WT1) is a transcription factor which plays a major role in cell proliferation, differentiation, survival, and apoptosis. WT1 was first identified as a tumor suppressor gene in Wilms' tumor. The expression of survival signaling genes, IL-2, IL-2RB, and IL-2RG, was also suppressed after WT1-siRNA treatment. In addition, the WT1 silencing also inhibited the S phase of the cell cycle and induced cell death.Moreover, transcriptional modulation of IL-2, IL-2RB, and IL2-2RG expression by WT1 was likely involved in this phenotypic change. |
| Molecular Mass | The protein has a predicted MW of 51.3 kDa (IL-2 R beta) and 54.6 kDa (IL-2 R gamma). Due to glycosylation, the protein migrates to 65-70 kDa and 80-100 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Ala27-Thr240(IL-2 R beta) & Leu23-Ala262(IL-2 R gamma) |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P14784(IL-2 R beta)&P31785-1(IL-2 R gamma) |
| Amino Acid Sequence | Recombinant Human IL-2 R beta&IL-2 R gamma Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus of IL-2 R beta and IL-2 R gamma.It contains Ala27-Thr240 (IL-2 R beta) and Leu23-Ala262 (IL-2 R gamma). |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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