Biotinylated Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein (ITG-HM4V1B)
SKU: BTL-KB-P-02228 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | ITG-HM4V1B |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Biotinylated Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein is expressed as a heterodimer of ITGAV and ITGB1 by co-expression in HEK293. Subunit ITGAV is fused with a His tag and a Avi tag at the C-terminus and subunit ITGB1 contains no tag.It contains Phe31-Val992 (ITGAV) acidic tail and Gln21-Asp728 (ITGB1) basic tail. |
| Target | Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE;> 90% as determined by HPLC |
| Scientific Background | Integrins are transmembrane heterodimeric receptors that contribute to diverse biological functions and play a conserved role in mediating cell adhesion to fixed extracellular ligands and in the maintenance of tissue integrity. αVβ1 is the major integrin on several different primary fibroblasts responsible for binding to TGFb1 LAP and for mediating activation of latent TGFb by these cells. |
| Molecular Mass | The protein has a predicted MW of 114 kDa (ITGAV) and 83.2 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-170 kDa (ITGAV) and 105-135 kDa (ITGB1) based on Bis-Tris PAGE result. |
| Sl Sequence | Phe31-Val992 (ITGAV) acidic tail & Gln21-Asp728 (ITGB1) basic tail |
| Appearance | Liquid |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P06756-1(ITGAV)&P05556-1(ITGB1) |
| Amino Acid Sequence | Recombinant Biotinylated Human Integrin alpha V beta 1 (ITGAV&ITGB1) Heterodimer Protein is expressed as a heterodimer of ITGAV and ITGB1 by co-expression in HEK293. Subunit ITGAV is fused with a His tag and a Avi tag at the C-terminus and subunit ITGB1 contains no tag.It contains Phe31-Val992 (ITGAV) acidic tail and Gln21-Asp728 (ITGB1) basic tail. |
| Storage | Valid for 12 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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