Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein (ITG-MM1A1)
SKU: BTL-KB-P-02239 |
Host: Mouse |
Brand: Kactus Bio
Product Description
| Cat Number | ITG-MM1A1 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of ITGA1.It contains Phe29-Pro1141(ITGA1) acidic tail and Gln21-Asp728(ITGB1) basic tail. |
| Target | Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer |
| Host | Mouse |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | Integrin α1β1 is a heterodimer of the Integrin subunits alpha 1 and beta 1 and is one of four collagen‑binding integrins, it preferentially binds Collagens I, IV, VI, XIII and XVI, but also binds Laminin. Integrin α1β1 is widely expressed in mesenchyme and the immune system, as well as a minority of epithelial tissues. It can suppresse EGFR signaling, increase expression of Caveolin-1, reduce production of reactive oxygen species, regulate collagen expression, regulate MMP collagenase and gelatinase activity, and mediates the renal basement membrane disorder Alport syndrome. |
| Molecular Mass | The protein has a predicted MW of 129.00 kDa (ITGA1) & 82.80 kDa (ITGB1). Due to glycosylation, the protein migrates to 140-200 kDa (ITGA1) and 100-115 kDa (ITGB1) based on Bis-Tris PAGE result. |
| Sl Sequence | Phe29-Pro1141(ITGA1) acidic tail & Gln21-Asp728(ITGB1) basic tail |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | Q3V3R4(ITGA1)&P09055-1(ITGB1) |
| Amino Acid Sequence | Recombinant Mouse Integrin alpha 1 beta 1 (ITGA1&ITGB1) Heterodimer Protein is expressed from HEK293 with His tag at the C-Terminus of ITGA1.It contains Phe29-Pro1141(ITGA1) acidic tail and Gln21-Asp728(ITGB1) basic tail. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
Share Item: