Cynomolgus Kallikrein 5/KLK5 Protein (active form) (KLK-CM105)
SKU: BTL-KB-P-02274 |
Host: Cynomolgus |
Brand: Kactus Bio
Product Description
| Cat Number | KLK-CM105 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Cynomolgus Kallikrein 5/KLK5 Protein (active form) is expressed from HEK293 with His tag at the C-terminus.It contains Ile65-Ser291. |
| Target | Kallikrein 5/KLK5 |
| Host | Cynomolgus |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | The inhibition of kallikrein 5 (KLK5) has been identified as a potential strategy for treatment of the genetic skin disorder Netherton syndrome, in which loss-of-function mutations in the SPINK5 gene lead to down-regulation of the endogenous inhibitor LEKTI-1 and profound skin-barrier defects with severe allergic manifestations. To aid in the development of a medicine for this target, an X-ray crystallographic system was developed to facilitate fragment-guided chemistry and knowledge-based drug-discovery approaches. |
| Molecular Mass | The protein has a predicted MW of 26.64 kDa. Due to glycosylation, the protein migrates to 38-52 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Ile65-Ser291 |
| Solubility | Dissolve the lyophilized protein in 20mM NaAc, 150mM NaCl (pH 5.0). It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | XP_005590112.3 |
| Amino Acid Sequence | Recombinant Cynomolgus Kallikrein 5/KLK5 Protein (active form) is expressed from HEK293 with His tag at the C-terminus.It contains Ile65-Ser291. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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