Cynomolgus LILRA4/CD85g Protein (LIL-CM1A4)
SKU: BTL-KB-P-02382 |
Host: Cynomolgus |
Brand: Kactus Bio
Product Description
| Cat Number | LIL-CM1A4 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Cynomolgus LILRA4/CD85g Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu24-Asn446. |
| Target | LILRA4/CD85g |
| Host | Cynomolgus |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | LILRA4, also known as ILT7 and CD85g, is an approximately 60-70 kDa variably glycosylated transmembrane protein that regulates immune cell activation. Mature human LILRA4 consists of a 423 amino acid (aa) extracellular domain (ECD) with four immunoglobulin-like domains, a 21 aa transmembrane segment, and a 32 aa cytoplasmic domain.LILRA4 function coreceptor to limit the innate immune responses to viral infections; signaling occurs via FCER1G (PubMed:16735691, PubMed:19564354). Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as negative regulator of TLR7 and TLR9 signaling cascades. |
| Molecular Mass | The protein has a predicted MW of 47.7 kDa. Due to glycosylation, the protein migrates to 58-68 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Glu24-Asn446 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | XP_005590346.1 |
| Amino Acid Sequence | Recombinant Cynomolgus LILRA4/CD85g Protein is expressed from HEK293 with His tag at the C-Terminus.It contains Glu24-Asn446. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
Share Item: