Product Description
| Cat Number | LRP-HM205 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Glu644-Gln1263. |
| Target | LRP-5 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Scientific Background | A role for low-density lipoprotein-related receptor 5 (LRP5) in human bone was first established by the identification of genetic alterations that led to dramatic changes in bone mass. Shortly thereafter, mutations that altered the function of the sclerostin (SOST) gene were also associated with altered human bone mass. Subsequent studies of LRP5 and sclerostin have provided important insights into the mechanisms by which these proteins regulate skeletal homeostasis. |
| Molecular Mass | The protein has a predicted MW of 96.51 kDa. Due to glycosylation, the protein migrates to 100-115 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Glu644-Gln1263 |
| Appearance | Liquid |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | O75197-1 |
| Amino Acid Sequence | Recombinant Human LRP-5 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Glu644-Gln1263. |
| Storage | Valid for 12 months from date of receipt when stored at -80°C.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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