PE-Labeled Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Tetramer Protein (MHC-HE450TP)
SKU: BTL-KB-P-02622 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | MHC-HE450TP |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant PE-Labeled Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Tetramer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. PE-Labeled Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin.It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide. |
| Target | HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) |
| Host | Human |
| Scientific Background | The nucleophosmin (NPM1) mutant protein, a leukemia-associated antigen characterized by its leukemia-restricted expression and immunogenic potential, has emerged as a promising therapeutic target for acute myeloid leukemia (AML) immunotherapy. Among its immunogenic epitopes, the CLAVEEVSL peptide derived from the full C-terminal region of the NPM1-mutated isoform demonstrates potent immunogenicity, making it a prime candidate for T cell-based immunotherapies. |
| Sl Sequence | Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide |
| Appearance | Liquid |
| Expression System | E.coli |
| Gene Id | A0A140T913(HLA-A*02:01)&P61769(B2M)&CLAVEEVSL |
| Amino Acid Sequence | Recombinant PE-Labeled Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Tetramer Protein is expressed from E.coli with His tag and Avi tag at the C-terminus. PE-Labeled Human HLA-A*02:01&B2M&NPM1-CLAV (CLAVEEVSL) Tetramer is assembled by biotinylated monomer and PE-labeled streptavidin.It contains Gly25-Thr305(HLA-A*02:01), Ile21-Met119(B2M) and CLAVEEVSL peptide. |
| Storage | Valid for 6 months from date of receipt when stored at -80°C.； Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| Note | The product is for research use only |
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