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ICI 182,780

SKU: BTL-IB-P-00161 | Brand: Isca Biochemical
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Product Description

Cat Number NR-210
Category Peptide
Pack Size 5 mg
Description Estrogen receptor antagonist
Purity >98% by hplc, NMR conforms
Biomarker Target Nuclear receptor modulators
Sequence Three Letter Code 7α,17β-[9-[(4,4,5,5,5-Pentafluoropentyl)sulfinyl]nonyl]estra-1,3,5(10)-triene-3,17-diol
Molecular Formula C32H47F5O3S
Solubility Soluble in DMSO (60 mg/mL) and ethanol (30 mg/mL)
Appearance White solid
Storage Store dry, frozen and in the dark
References Howell et al (2001) ICI 182,780 (Faslodex): development of a novel, "pure" antiestrogen. Cancer 89(4) 817 PMID: 10951345Wardley (2002) Fulvestrant: a review of its development, pre-clinical and clinical data. Int J Clin Pract. 56(4) 305 PMID: 12074216Thomas et al (2005) Identity of an estrogen membrane receptor coupled to a G protein in human breast cancer cells. Endocrinology 146(2) 624 PMID: 15539556Deeks (2018) Fulvestrant: A Review in Advanced Breast Cancer Not Previously Treated with Endocrine Therapy. Drugs 78(1) 131 PMID: 29270913
Related areas
All small molecules >All nuclear receptor modulators >All cancer research categories >All endocrinology research categories >
Note The product is for research use only
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