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Hoe 140

SKU: BTL-IB-P-00159 | Brand: Isca Biochemical

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Product Description

Cat Number	PN-090
Category	Peptide
Pack Size	1 mg
Description	Bradykinin B2 receptor antagonist
Modification	Arg-1 is D-Arg, X-4 is Hyp, X-6 is Thi, X-8 is D-Tic, X-9 is Oic
Purity	>95% by HPLC
Biomarker Target	Bradykinin receptors
Sequence Three Letter Code	H-(D)Arg-Arg-Pro-Hyp-Gly-Thi-Ser-(D)Tic-Oic-Arg-OH
Molecular Formula	C59H89N19O13S
Sl Sequence	RRPXGXSXXR
Solubility	Soluble to 1 mg/ml in water
Appearance	Freeze dried solid
Storage	Store desiccated, frozen and in the dark
References	Hock et al (1991) Hoe 140 a new potent and long acting bradykinin-antagonist: in vitro studies. Br.J.Pharmacol. 102 769 PMID: 1364851Perkins et al (1993) Antinociceptive activity of the bradykinin B1 and B2 receptor antagonists, des-Arg9, [Leu8]-BK and HOE 140, in two models of persistent hyperalgesia in the rat. Pain 53(2) 191 PMID: 8393171Bawolak et al (2006) The bradykinin B2 receptor antagonist icatibant (Hoe 140) blocks aminopeptidase N at micromolar concentrations: off-target alterations of signaling mediated by the bradykinin B1 and angiotensin receptors. Eur.J.Pharmacol. 551 108 PMID: 17026984 Related areas_x000D_ All peptides >All bradykinin receptor modulators > All pain research categories >
Note	The product is for research use only

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