Mouse CD45/PTPRC Protein (PTP-MM201)
SKU: BTL-KB-P-03305 |
Host: Mouse |
Brand: Kactus Bio
Product Description
| Cat Number | PTP-MM201 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Mouse CD45/PTPRC Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln26-Lys427. |
| Target | CD45/PTPRC |
| Host | Mouse |
| Purity | > 95% as determined by Bis-Tris PAGE;> 95% as determined by HPLC |
| Scientific Background | PTPRC (also known as CD45),T cells require the protein tyrosine phosphatase CD45 to detect and respond to antigen because it activates the Src family kinase Lck, which phosphorylates the T cell antigen receptor (TCR) complex. CD45 ativates Lck by opposing the negative regulatory kinase Csk. Paradoxically, CD45 has also been implicated in suppressing TCR signaling by dephosphorylating the same signaling motifs within the TCR complex upon which Lck acts. |
| Molecular Mass | The protein has a predicted MW of 71.46 kDa. Due to glycosylation, the protein migrates to 100-130 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Gln26-Lys427 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | P06800-6 |
| Amino Acid Sequence | Recombinant Mouse CD45/PTPRC Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Gln26-Lys427. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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