Product Description
| Cat Number | SEZ-HM206 |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human SEZ6 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu20-His925. |
| Target | SEZ6 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Scientific Background | Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface. |
| Molecular Mass | The protein has a predicted MW of 124.53 kDa. Due to glycosylation, the protein migrates to 140-200 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Leu20-His925 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 1 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | Q53EL9-1 |
| Amino Acid Sequence | Recombinant Human SEZ6 Protein is expressed from HEK293 with hFc (IgG1) tag at the C-Terminus.It contains Leu20-His925. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
Share Item: