Human TIM-3/HAVCR2 Protein, Ultra Low Endotoxin (TIM-HM631-UL)
SKU: BTL-KB-P-03663 |
Host: Human |
Brand: Kactus Bio
Product Description
| Cat Number | TIM-HM631-UL |
|---|---|
| Category | Recombinant Protein |
| Pack Size | 100UG |
| Description | Recombinant Human TIM-3/HAVCR2 Protein is expressed from HEK293 with Llama Fc tag at the C--terminus.It contains Ser22-Arg200. |
| Target | TIM-3/HAVCR2 |
| Host | Human |
| Purity | > 95% as determined by Bis-Tris PAGE |
| Scientific Background | Hepatitis A virus cellular receptor 2 (HAVCR2), also known as T-cell immunoglobulin and mucin-domain containing-3 (TIM-3), is a protein that in humans is encoded by the HAVCR2 gene.TIM3 is an immune checkpoint and together with other inhibitory receptors including programmed cell death protein 1 (PD-1) and lymphocyte activation gene 3 protein (LAG3) mediate the CD8 T-cell exhaustion. TIM3 has also been shown as a CD4 Th1-specific cell surface protein that regulates macrophage activation and enhances the severity of experimental autoimmune encephalomyelitis in mice. |
| Molecular Mass | The protein has a predicted MW of 47.18 kDa. Due to glycosylation, the protein migrates to 70-90 kDa based on Bis-Tris PAGE result. |
| Sl Sequence | Ser22-Arg200 |
| Solubility | Dissolve the lyophilized protein in distilled water. It is recommended to resuspend at 0.5 mg/mL if the lyophilized powder is 100 μg or less, at 1mg/ml for 500μg or 1mg lyophilized powder. Do not mix by vortex or vigorous shaking. |
| Appearance | Lyophilized |
| Endotoxin Levels | Less than 0.001 EU per μg by the LAL method. |
| Expression System | HEK293 |
| Gene Id | Q8TDQ0-1 |
| Amino Acid Sequence | Recombinant Human TIM-3/HAVCR2 Protein is expressed from HEK293 with Llama Fc tag at the C--terminus.It contains Ser22-Arg200. |
| Storage | -20 to -80°C for 12 months as supplied from date of receipt.；-80°C for 3 months after reconstitution.；Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles. |
| View Document | |
| Note | The product is for research use only |
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