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Etomoxir

SKU: BTL-IB-P-00120 | Brand: Isca Biochemical

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Product Description

Cat Number	TR-010
Category	Peptide
Pack Size	5 mg
Description	Carnitine palmitoyltransferase inhibitor
Purity	98% by HPLC, NMR conforms
Biomarker Target	Transferases
Sequence Three Letter Code	(R)-(+)-2-[6-(4-Chlorophenoxy)hexyl]-oxirane-2-carboxylic acid sodium salt
Molecular Formula	C15H18ClO4 €¢ Na
Solubility	Soluble to 5mg per ml in water
Appearance	White solid
Storage	Store dry, frozen and in the dark
References	Agius et al (1991) Stereospecificity of the inhibition by etomoxir of fatty acid and cholesterol synthesis in isolated rat hepatocytes. Biochem Pharmacol. 42(9) 1717 PMID: 1930298Rupp et al (1992) Modification of subcellular organelles in pressure-overloaded heart by etomoxir, a carnitine palmitoyltransferase I inhibitor. FASEB J.6(6) 2349 PMID: 1531968Xu et al (2003) Etomoxir mediates differential metabolic channeling of fatty acid and glycerol precursors into cardiolipin in H9c2 cells. J Lipid Res. 44(2) 415 PMID: 12576524Pike et al (2011) Inhibition of fatty acid oxidation by etomoxir impairs NADPH production and increases reactive oxygen species resulting in ATP depletion and cell death in human glioblastoma cells. Biochim Biophys Acta. 1807(6) 726 PMID: 21692241Yao et al (2018) Identifying off-target effects of etomoxir reveals that carnitine palmitoyltransferase I is essential for cancer cell proliferation independent of β-oxidation. PLoS Biol. 16(3) e2003782 PMID: 29596410 Related areas All small molecules >All transferase modulators >All cardiovascular research categories >All diabetes research categories >All cancer research categories >
Note	The product is for research use only

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