Autotaxin-Lysophosphatidic Acid Pathway Products

The Autotaxin-Lysophosphatidic Acid (ATX-LPA) axis is a well characterized signalling pathway that is known to be aberrantly regulated in many types of cancer. ATX remains an attractive target for drug discovery due to its role in the tumour microenvironment and chronic inflammation.

The ATX-LPA axis is involved in wound healing response, where it induces platelet aggregation, lymphocyte homing, cytokine production, keratinocyte migration, proliferation, and differentiation under physiological conditions. When acute inflammation becomes chronic in unpaired homeostasis, ATX-LPA signalling induces an augmented cytokine production and lymphocyte infiltration, aggravating the inflammation in conditions such as asthma, pulmonary fibrosis, and rheumatoid arthritis, to name a few.

In cancer context, it also promotes cell survival, proliferation, migration, invasion, and angiogenesis, enhancing its progression in a state similar to a “wound that never heals”. Hence to promote research in cancer related to Autotaxin-Lysophosphatidic Acid (ATX-LPA) axis we Biotechno Labs along with its eminent Principal Echelon Biosciences is providing different related products including Assays, ELISA, Antibodies, Proteins, Inhibitors and Lipids.