Biochemical Kinase Screening and Profiling Services

Protein kinases are the enzymes that regulates the cell growth and proliferation and also regulates the immune responses. Hence these kinases are an important therapeutic target for various diseases including cancer. Therefore, we Biotechno Labs is providing Biochemical Kinase screening and profiling services from Carna Biosciences. Carna offers >320 biochemical screening and profiling assays for assessing potency and selectivity of sample compounds. There are three assay platforms for the screening which allows them to interrogate a wide range of kinase targets using stringent SOPs. They offer testing at higher ATP concentration (1mM) for providing the vision in compound inhibition and the efficacy under more physiologically relevant conditions, along the ~ATP Km assay services. The company also provide Pre-incubation services which can be utilized for the study of slow binding compounds which involves 30 mins preincubation of target kinases with the test compound at room temperature prior to measuring activity in the standard Mobility Shift Assay. Apart form this they also have selected panel series which are well-suited for an initial profiling of sample compounds.

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Carna Biosciences